{"id":10871,"date":"2024-01-23T12:09:59","date_gmt":"2024-01-23T12:09:59","guid":{"rendered":"https:\/\/olmix.com\/new-biomarkers-for-exposure-to-fumonisins-in-chickens\/"},"modified":"2024-02-12T10:13:07","modified_gmt":"2024-02-12T10:13:07","slug":"de-nouveaux-biomarqueurs-de-lexposition-aux-fumonisines-chez-le-poulet","status":"publish","type":"post","link":"https:\/\/olmix.com\/fr\/de-nouveaux-biomarqueurs-de-lexposition-aux-fumonisines-chez-le-poulet\/","title":{"rendered":"De nouveaux biomarqueurs de l\u2019exposition aux fumonisines chez le poulet ?"},"content":{"rendered":"[vc_row type=\u00a0\u00bbin_container\u00a0\u00bb full_screen_row_position=\u00a0\u00bbmiddle\u00a0\u00bb column_margin=\u00a0\u00bbdefault\u00a0\u00bb column_direction=\u00a0\u00bbdefault\u00a0\u00bb column_direction_tablet=\u00a0\u00bbdefault\u00a0\u00bb column_direction_phone=\u00a0\u00bbdefault\u00a0\u00bb scene_position=\u00a0\u00bbcenter\u00a0\u00bb constrain_group_4=\u00a0\u00bbyes\u00a0\u00bb 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gradient_type=\u00a0\u00bbdefault\u00a0\u00bb][nectar_icon icon_family=\u00a0\u00bbfontawesome\u00a0\u00bb icon_style=\u00a0\u00bbdefault\u00a0\u00bb icon_color_type=\u00a0\u00bbcolor_scheme\u00a0\u00bb icon_color=\u00a0\u00bbExtra-Color-1″ icon_padding=\u00a0\u00bb0px\u00a0\u00bb pointer_events=\u00a0\u00bball\u00a0\u00bb icon_fontawesome=\u00a0\u00bbfa fa-clock-o\u00a0\u00bb icon_size=\u00a0\u00bb15″ margin_right=\u00a0\u00bb7px\u00a0\u00bb margin_top=\u00a0\u00bb1px\u00a0\u00bb][vc_column_text]Reading Time:<\/span> 3<\/span> minutes<\/span><\/span>[\/vc_column_text][\/vc_column_inner][\/vc_row_inner][vc_row_inner column_margin=\u00a0\u00bbdefault\u00a0\u00bb column_direction=\u00a0\u00bbdefault\u00a0\u00bb column_direction_tablet=\u00a0\u00bbdefault\u00a0\u00bb column_direction_phone=\u00a0\u00bbdefault\u00a0\u00bb top_padding=\u00a0\u00bb2%\u00a0\u00bb constrain_group_1=\u00a0\u00bbyes\u00a0\u00bb bottom_padding=\u00a0\u00bb2%\u00a0\u00bb text_align=\u00a0\u00bbleft\u00a0\u00bb row_position=\u00a0\u00bbdefault\u00a0\u00bb row_position_tablet=\u00a0\u00bbinherit\u00a0\u00bb row_position_phone=\u00a0\u00bbinherit\u00a0\u00bb overflow=\u00a0\u00bbvisible\u00a0\u00bb pointer_events=\u00a0\u00bball\u00a0\u00bb][vc_column_inner column_padding=\u00a0\u00bbpadding-2-percent\u00a0\u00bb column_padding_tablet=\u00a0\u00bbinherit\u00a0\u00bb column_padding_phone=\u00a0\u00bbinherit\u00a0\u00bb column_padding_position=\u00a0\u00bbleft\u00a0\u00bb left_margin=\u00a0\u00bb7px\u00a0\u00bb column_element_direction_desktop=\u00a0\u00bbdefault\u00a0\u00bb column_element_spacing=\u00a0\u00bbdefault\u00a0\u00bb desktop_text_alignment=\u00a0\u00bbdefault\u00a0\u00bb tablet_text_alignment=\u00a0\u00bbdefault\u00a0\u00bb phone_text_alignment=\u00a0\u00bbdefault\u00a0\u00bb background_color_opacity=\u00a0\u00bb1″ background_hover_color_opacity=\u00a0\u00bb1″ column_backdrop_filter=\u00a0\u00bbnone\u00a0\u00bb column_shadow=\u00a0\u00bbnone\u00a0\u00bb column_border_radius=\u00a0\u00bbnone\u00a0\u00bb column_link_target=\u00a0\u00bb_self\u00a0\u00bb overflow=\u00a0\u00bbvisible\u00a0\u00bb gradient_direction=\u00a0\u00bbleft_to_right\u00a0\u00bb overlay_strength=\u00a0\u00bb0.3″ width=\u00a0\u00bb1\/1″ tablet_width_inherit=\u00a0\u00bbdefault\u00a0\u00bb animation_type=\u00a0\u00bbdefault\u00a0\u00bb bg_image_animation=\u00a0\u00bbnone\u00a0\u00bb border_type=\u00a0\u00bbadvanced\u00a0\u00bb border_left_desktop=\u00a0\u00bb1″ column_border_color=\u00a0\u00bb#269756″ column_border_style=\u00a0\u00bbsolid\u00a0\u00bb column_padding_type=\u00a0\u00bbdefault\u00a0\u00bb gradient_type=\u00a0\u00bbdefault\u00a0\u00bb][vc_column_text el_class=\u00a0\u00bbmed\u00a0\u00bb]La toxicit\u00e9 des fumonisines (FUM) est associ\u00e9e au blocage des c\u00e9ramide synthases (CerS), qui affecte l’\u00e9quilibre des sphingolipides comme la sphinganine (Sa) et la sphingosine (So) dans les cellules.<\/b> Tandis que Sa s’accumule dans les cellules, le niveau de So est compens\u00e9, affectant ainsi le ratio Sa:So qui est utilis\u00e9 comme biomarqueur de l’exposition aux fumonisines chez de nombreuses esp\u00e8ces.<\/span>[\/vc_column_text][\/vc_column_inner][\/vc_row_inner][vc_row_inner column_margin=\u00a0\u00bbdefault\u00a0\u00bb column_direction=\u00a0\u00bbdefault\u00a0\u00bb column_direction_tablet=\u00a0\u00bbdefault\u00a0\u00bb column_direction_phone=\u00a0\u00bbdefault\u00a0\u00bb top_padding=\u00a0\u00bb2%\u00a0\u00bb constrain_group_1=\u00a0\u00bbyes\u00a0\u00bb bottom_padding=\u00a0\u00bb2%\u00a0\u00bb text_align=\u00a0\u00bbleft\u00a0\u00bb row_position=\u00a0\u00bbdefault\u00a0\u00bb row_position_tablet=\u00a0\u00bbinherit\u00a0\u00bb row_position_phone=\u00a0\u00bbinherit\u00a0\u00bb overflow=\u00a0\u00bbvisible\u00a0\u00bb pointer_events=\u00a0\u00bball\u00a0\u00bb][vc_column_inner column_padding=\u00a0\u00bbno-extra-padding\u00a0\u00bb column_padding_tablet=\u00a0\u00bbinherit\u00a0\u00bb column_padding_phone=\u00a0\u00bbinherit\u00a0\u00bb column_padding_position=\u00a0\u00bball\u00a0\u00bb column_element_direction_desktop=\u00a0\u00bbdefault\u00a0\u00bb column_element_spacing=\u00a0\u00bbdefault\u00a0\u00bb desktop_text_alignment=\u00a0\u00bbdefault\u00a0\u00bb tablet_text_alignment=\u00a0\u00bbdefault\u00a0\u00bb phone_text_alignment=\u00a0\u00bbdefault\u00a0\u00bb background_color_opacity=\u00a0\u00bb1″ background_hover_color_opacity=\u00a0\u00bb1″ column_backdrop_filter=\u00a0\u00bbnone\u00a0\u00bb column_shadow=\u00a0\u00bbnone\u00a0\u00bb column_border_radius=\u00a0\u00bbnone\u00a0\u00bb column_link_target=\u00a0\u00bb_self\u00a0\u00bb overflow=\u00a0\u00bbvisible\u00a0\u00bb gradient_direction=\u00a0\u00bbleft_to_right\u00a0\u00bb overlay_strength=\u00a0\u00bb0.3″ width=\u00a0\u00bb1\/1″ tablet_width_inherit=\u00a0\u00bbdefault\u00a0\u00bb animation_type=\u00a0\u00bbdefault\u00a0\u00bb bg_image_animation=\u00a0\u00bbnone\u00a0\u00bb border_type=\u00a0\u00bbsimple\u00a0\u00bb column_border_width=\u00a0\u00bbnone\u00a0\u00bb column_border_style=\u00a0\u00bbsolid\u00a0\u00bb][vc_column_text]Cependant, <\/span>les m\u00e9canismes compensatoires pour maintenir le niveau de c\u00e9ramides dans les cellules<\/b> rendent non pertinente l’utilisation de ce biomarqueur dans certaines \u00e9tudes (en fonction du niveau et de la dur\u00e9e d’exposition). Justement, dans cette \u00e9tude, <\/span>le ratio Sa:So n’a pas \u00e9t\u00e9 significativement affect\u00e9 dans le plasma des poulets expos\u00e9s aux fumonisines<\/b>. <\/span><\/p>\n

Toutefois, une <\/span>analyse compl\u00e8te<\/b> des diff\u00e9rentes classes de sphingolipides<\/b> a r\u00e9v\u00e9l\u00e9 que le ratio des formes phosphat\u00e9es de Sa et So (Sa1P:So1P) \u00e9tait significativement augment\u00e9 par l’administration de fumonisines. Ce r\u00e9sultat est coh\u00e9rent avec des r\u00e9sultats pr\u00e9c\u00e9dents sugg\u00e9rant que le ratio Sa1P:So1P est un meilleur biomarqueur de l\u2019exposition aux fumonisines dans le plasma que le ratio Sa:So. Des effets similaires des fumonisines ont \u00e9t\u00e9 observ\u00e9s en fonction de la taille de la cha\u00eene carbon\u00e9e des c\u00e9ramides. <\/span><\/p>\n

Une augmentation significative du ratio C22-C24:C16 a \u00e9t\u00e9 observ\u00e9e dans le plasma. Bien que les m\u00e9canismes \u00e0 l’origine de ces effets ne soient pas encore compris, ce r\u00e9sultat sugg\u00e8re que les <\/span>ratios des sphingolipides C22-C24:C16, en conjonction avec le ratio Sa1P:So1P, pourraient \u00eatre de bons candidats pour r\u00e9v\u00e9ler l’exposition aux fumonisines dans le plasma de poulet, \u00e0 des doses n\u2019ayant eu aucun effet sur le ratio Sa\u00a0:So<\/b>.<\/span>[\/vc_column_text][image_with_animation image_url=\u00a0\u00bb6291″ image_size=\u00a0\u00bbfull\u00a0\u00bb animation_type=\u00a0\u00bbentrance\u00a0\u00bb animation=\u00a0\u00bbNone\u00a0\u00bb animation_movement_type=\u00a0\u00bbtransform_y\u00a0\u00bb hover_animation=\u00a0\u00bbnone\u00a0\u00bb alignment=\u00a0\u00bb\u00a0\u00bb border_radius=\u00a0\u00bbnone\u00a0\u00bb box_shadow=\u00a0\u00bbnone\u00a0\u00bb image_loading=\u00a0\u00bbdefault\u00a0\u00bb max_width=\u00a0\u00bb100%\u00a0\u00bb max_width_mobile=\u00a0\u00bbdefault\u00a0\u00bb][vc_column_text]Figure : <\/span><\/em>Analyses discriminantes (PLS-DA) des sphingolipides dans le plasma de poulets nourris avec un r\u00e9gime t\u00e9moin exempt de mycotoxines ou contenant environ 15 mg de FUM\/kg pendant 14 ou 21 jours.<\/span><\/i>[\/vc_column_text][vc_column_text]R\u00e9f\u00e9rence : Lassallette E., Nyvall-Collen P., Guerre P., Targeted sphingolipidomics indicates increased C22-C24:16 ratios of virtually all assayed classes in liver, kidney, and plasma of fumonisin-fed chickens. Ecotoxicology and Environmental Safety 268 (2023) 115697. <\/span><\/i>https:\/\/doi.org\/10.1016\/j.ecoenv.2023.115697<\/span><\/i><\/a>\u00a0<\/span><\/i>[\/vc_column_text][divider line_type=\u00a0\u00bbFull Width Line\u00a0\u00bb line_thickness=\u00a0\u00bb1″ divider_color=\u00a0\u00bbaccent-color\u00a0\u00bb custom_height=\u00a0\u00bb20″][vc_column_text]Vous \u00eates int\u00e9ress\u00e9 par les travaux de cette \u00e9quipe de recherche sur les effets des fumonisines chez le poulet\u00a0?<\/b> Jetez un coup d’\u0153il \u00e0 leur \u00e9tude pr\u00e9c\u00e9dente<\/a> sur l’<\/span>accumulation de FUM dans le foie et les muscles du poulet, et sur la fa\u00e7on dont la technologie Algoclay d\u2019Olmix peut la r\u00e9duire<\/b>.<\/span>[\/vc_column_text][\/vc_column_inner][\/vc_row_inner][\/vc_column][\/vc_row][vc_row type=\u00a0\u00bbin_container\u00a0\u00bb full_screen_row_position=\u00a0\u00bbmiddle\u00a0\u00bb column_margin=\u00a0\u00bbdefault\u00a0\u00bb column_direction=\u00a0\u00bbdefault\u00a0\u00bb column_direction_tablet=\u00a0\u00bbdefault\u00a0\u00bb column_direction_phone=\u00a0\u00bbdefault\u00a0\u00bb scene_position=\u00a0\u00bbcenter\u00a0\u00bb text_color=\u00a0\u00bbdark\u00a0\u00bb text_align=\u00a0\u00bbleft\u00a0\u00bb row_border_radius=\u00a0\u00bbnone\u00a0\u00bb row_border_radius_applies=\u00a0\u00bbbg\u00a0\u00bb overflow=\u00a0\u00bbvisible\u00a0\u00bb overlay_strength=\u00a0\u00bb0.3″ gradient_direction=\u00a0\u00bbleft_to_right\u00a0\u00bb shape_divider_position=\u00a0\u00bbbottom\u00a0\u00bb bg_image_animation=\u00a0\u00bbnone\u00a0\u00bb][vc_column column_padding=\u00a0\u00bbno-extra-padding\u00a0\u00bb column_padding_tablet=\u00a0\u00bbinherit\u00a0\u00bb column_padding_phone=\u00a0\u00bbinherit\u00a0\u00bb column_padding_position=\u00a0\u00bball\u00a0\u00bb column_element_direction_desktop=\u00a0\u00bbdefault\u00a0\u00bb column_element_spacing=\u00a0\u00bbdefault\u00a0\u00bb desktop_text_alignment=\u00a0\u00bbdefault\u00a0\u00bb tablet_text_alignment=\u00a0\u00bbdefault\u00a0\u00bb phone_text_alignment=\u00a0\u00bbdefault\u00a0\u00bb background_color_opacity=\u00a0\u00bb1″ background_hover_color_opacity=\u00a0\u00bb1″ column_backdrop_filter=\u00a0\u00bbnone\u00a0\u00bb column_shadow=\u00a0\u00bbnone\u00a0\u00bb column_border_radius=\u00a0\u00bbnone\u00a0\u00bb column_link_target=\u00a0\u00bb_self\u00a0\u00bb column_position=\u00a0\u00bbdefault\u00a0\u00bb gradient_direction=\u00a0\u00bbleft_to_right\u00a0\u00bb overlay_strength=\u00a0\u00bb0.3″ width=\u00a0\u00bb1\/1″ tablet_width_inherit=\u00a0\u00bbdefault\u00a0\u00bb animation_type=\u00a0\u00bbdefault\u00a0\u00bb bg_image_animation=\u00a0\u00bbnone\u00a0\u00bb border_type=\u00a0\u00bbsimple\u00a0\u00bb column_border_width=\u00a0\u00bbnone\u00a0\u00bb column_border_style=\u00a0\u00bbsolid\u00a0\u00bb][vc_column_text]\n[\/vc_column_text][\/vc_column][\/vc_row]\n","protected":false},"excerpt":{"rendered":"

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